Molecular Mechanisms of Drug Resistance in Glioblastoma

Molecular mechanisms of drug resistance.

Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.

Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing to its inherently profound resistance towards current standards of therapy. Considerable effort is being devoted to identifying the molecular basis of temozolomide resistance in GBMs and exploring novel therapeutic regimens that may improve overall survival. Several independent DNA repair mechanisms that norma...

Molecular mechanisms in multiple myeloma drug resistance.

Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from a plasma cell, which produces and secretes non-functioning immunoglobulins. Most MM cells are sensitive to prote...

Molecular mechanisms involved in multidrug resistance in breast cancer therapy

Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...

Mechanisms of Cell Resistance in Glioblastoma Multiforme

Glioblastoma multiforme is the most common brain tumor in adults. It is characterized by a rapid clinical course and extremely unfavorable prognosis. The etiology and the molecular pathogenetic mechanisms are not entirely clear yet. Active proliferation, resistance to apoptosis and high angiogenicity are basic factors limiting the effect of standard therapy. A significant problem is the resista...